Seriously, making manuscript figures has always been the bane of my existence. Photoshop is a massive PITA to use (as is its freeware cousin GIMP), and you can't really move things around in Paint without severely fucking up image quality.
And then there's powerpoint... which should suck most of all, but is somehow amazing. I can arrange individual pictures in any way I want, hit ctrl a, save as picture, select high-quality format, and BAM, instant manuscript figure.
The fact that I did not know this before makes me really, really sad, but even so: