What am I doing wrong (job search-related woes)

I send out resumes (in response to job postings), applications, cover letters, etc. for jobs that I am qualified for, and have experience doing, yet I never receive any calls/emails for said jobs. I'm wondering what exactly I might be doing wrong. Should I be following up a few days after I submit my resume/cover letter? Am I doing my cover letters wrong, i.e., not using the keywords?

HELP PLEASE! I need to get hired asap.

Can any GTers help me out? My situation is getting more desperate by the day.

What am I doing wrong (job search-related woes)

Edited for clarity.